Download Analogue-based Drug Discovery II, Volume 2 by János Fischer, C. Robin Ganellin PDF

By János Fischer, C. Robin Ganellin

Born out of a venture of the IUPAC's committee on Medicinal Chemistry and Drug improvement, this reference addresses prior and present techniques for profitable drug analog improvement, extending the formerly released quantity through 9 new analog sessions and 8 case experiences. Like its precursor, this quantity additionally features a common part discussing universally appropriate suggestions for analog discovery and improvement. Spanning quite a lot of healing fields and chemical periods, the 2 volumes jointly represent the 1st systematic method of drug analog development.Of curiosity to nearly each researcher operating in drug discovery and pharmaceutical chemistry.

Show description

Read or Download Analogue-based Drug Discovery II, Volume 2 PDF

Similar nonfiction_4 books

Make yourself memorable: winning stategies to help you make a great impression on your boss, your co-workers, your customers--and everyone else!

This paintings deals techniques and methods for buying the substance, kind and correct feel of timing which are valuable for achievement. It explains the standards that may effect enterprise judgements, the features that galvanize, and the way to exploit persuasion on your virtue.

Proactive Child Protection and Social Work (Transforming Social Work Practice)

This booklet is helping scholars to appreciate the basic function of the social employee within the proactive safeguard of susceptible young ones and teens from abuse. content material: conceal; identify; Copyright; Contents; Acknowledgements; creation: criminal safeguards and protecting procedures; 1 Emotional abuse; 2 Sexual abuse; three forget; four actual abuse; end; References; Index.

Extra resources for Analogue-based Drug Discovery II, Volume 2

Sample text

In 2008, Imming and coworkers described N-(1H-indazol-5-yl)acetamide and N-(4-hydroxybenzyl)acetamide, which displayed analgesic activities comparable to paracetamol [15]. 4) try to avoid the formation of NAPQI. More time is needed to evaluate these efforts to optimize paracetamol. 3 Formation of N-acetyl-p-benzoquinone imine. 4 Some direct analogues of paracetamol (experimental phase). 2 Acetylsalicylic Acid (Aspirin) Willow bark [16] and leaves have been used as antipyretic and anti-inflammatory analgesics in ancient civilizations.

Aliment. Pharmacol. , 9, 363–378. T. A. L. Lemke), Lippincott Williams & Wilkins, Philadelphia. A. J. L. S. L. Parker), McGraw-Hill, New York. B. (2004) The Organic Chemistry of Drug Design and Drug Action, 2nd edn, Elsevier/Academic Press, p. 273. Erika M. , Gyömro˝i út 19/21, 1103 Budapest, Hungary Erika M. Alapi was born in Pasztó, Hungary, in 1974. She received her MSc degree in chemistry at the Faculty of Science of E€otv€os Lorand University in Budapest. She is working as a medicinal chemist in the field of CNS and preparing her PhD thesis “Optimizing Therapy by Analogues” under the supervision of Professor Janos Fischer at Gedeon Richter Pharmaceutical Plc.

The book also discussed some examples of structural analogues, in which the similarity is limited to their chemical structures since they possess different pharmacological properties. We also proposed the term pharmacological analogues for drugs that have completely different chemical structures but similar pharmacological properties. Analogues are based on following a lead compound, and if this compound were a drug that opened up a new therapeutic treatment then we use the term pioneer drug. ” One can subdivide pioneer drugs into those that have analogues and those that do not.

Download PDF sample

Rated 4.86 of 5 – based on 44 votes